Article
Regulatory landscape enrichment analysis (RLEA): a computational toolkit for non-coding variant enrichment and cell type prioritization.
BMC bioinformatics - 7 May 2024
Rosean Samuel, Sosa Eric A, O'Shea Dónal, Raj Srilakshmi M, Seoighe Cathal, Greally John M
Abstract excerpt
BACKGROUND: As genomic studies continue to implicate non-coding sequences in disease, testing the roles of these variants requires insights into the cell type(s) in which they are likely to be mediating their effects. Prior methods for associating non-coding variants with cell types have involved approaches using linkage disequilibrium or ontological associations, incurring significant processing requirements....
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