Article

TGM2-mediated histone serotonylation is an epigenetic cardioprotective mechanism in HFpEF

2026-07-01

Abstract excerpt

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome with incompletely understood molecular mechanisms. Histone serotonylation is a recently identified epigenetic modification in which serotonin is covalently conjugated to glutamine 5 of histone H3 in H3K4me3-marked nucleosomes. Here, we investigated the role of transglutaminase 2 (TGM2)-mediated histone serotonylation in HFpEF. In a...

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Literature Corpus work: cb59471f-c741-5ed3-8fc1-af7c9a97175c
DOI: 10.64898/2026.06.25.734596

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