Article

Reactivation of a dormant developmental plasticity program drives synaptic rejuvenation and antidepressant-like responses

2025-01-04

Abstract excerpt

Antidepressants are widely used to treat mood and anxiety disorders, yet the cellular and molecular mechanisms underlying their therapeutic effects remain poorly understood. Here, we show that the selective serotonin reuptake inhibitor (SSRI) fluoxetine rejuvenates the dentate gyrus (DG) by reactivating a latent developmental plasticity program in mature neurons, which is required for re-engaging critical period-l...

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Literature Corpus work: cb570dff-14d5-57c6-a039-086493737632
DOI: 10.1101/2025.01.03.631260

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