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Article

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors.

Nature neuroscience - 1 Oct 2012

Rodenas-Ruano Alma, Chávez Andrés E, Cossio Maria J, Castillo Pablo E, Zukin R Suzanne

Abstract excerpt

NMDA receptors (NMDARs) are critical to synaptogenesis, neural circuitry and higher cognitive functions. A hallmark feature of NMDARs is an early postnatal developmental switch from those containing primarily GluN2B to primarily GluN2A subunits. Although the switch in phenotype has been an area o...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22960932
DOI: 10.1038/nn.3214
PMCID: PMC3501125

Genes

REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22960932-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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