Article

A Human Hippocampal Organoid Model with Sustained Neural Stem Cells Reveals State Shifts Under Glucocorticoid Stress

2025-11-04

Abstract excerpt

<h4>Summary</h4> The human hippocampus is a critical brain region for learning, memory, and stress regulation, distinguished by its ability to sustain neurogenesis after birth. This plasticity is driven by hippocampal neural stem cells (NSCs), which generate new neurons and maintain circuit integrity, but are highly sensitive to environmental and pathological influences. Mechanistic insight into human hippocampal...

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Literature Corpus work: 81e51e7c-7032-5ee3-a6d7-e4c2df540c79
DOI: 10.1101/2025.11.03.686207

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