Article

BRD1 haploinsufficiency alters early neuronal programming and disrupts maturation in human induced glutamatergic neurons

2026-02-16

Abstract excerpt

<title>Abstract</title> BRD1 is an epigenetic regulator implicated in neurodevelopmental and psychiatric disorders, yet its role in human neuronal differentiation, maturation, and function remains poorly understood. Here we show that <italic>BRD1</italic> haploinsufficiency disrupts early neuronal programming, resulting in accelerated maturation and altered neurodevelopmental trajectories in human induced...

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Literature Corpus work: d851b10f-0584-5efc-b8d0-04fa31380b51
DOI: 10.21203/rs.3.rs-8417267/v1

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