Article

Repetitive Neuronal Activation Regulates Cellular Maturation State via Nuclear Reprogramming

2025-05-08

Abstract excerpt

Neural stimulation, such as electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), are highly effective clinical interventions for a broad spectrum of psychiatric disorders, including depression and schizophrenia. However, their mechanism of action at the cellular level remains poorly understood. Here, we modelled ECT with repeated optogenetic neuronal stimulation in the mouse den...

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Literature Corpus work: 2947f150-8f3e-5246-ab25-e0c0696910fe
DOI: 10.1101/2025.05.02.651848

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