Article

Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation

2023-11-21

Abstract excerpt

The dentate gyrus of the hippocampus is important for many cognitive functions, including learning, memory, and mood. Here, we investigated age-associated changes in transcriptome-wide spatial gene expression in the human dentate gyrus across the lifespan. Genes associated with neurogenesis and the extracellular matrix were enriched in infants, while gene markers of inhibitory neurons and cell proliferation showed...

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Literature Corpus work: 8b0ed0d3-1dfb-5341-ae81-b6f6b05688f1
DOI: 10.1101/2023.11.20.567883

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