Article

The Gelation of CAG Repeat Expansion RNAs Suppresses Global Protein Translation

2021-06-07

Abstract excerpt

<title>Abstract</title> <p>RNA molecules with the expanded CAG repeat (eCAGr) may undergo liquid-to-gel phase transitions rapidly, but the nuclear eCAGr RNA foci display liquid-like properties, different from their gel-like behaviour in vitro (ref.1). The functional impact of this RNA gelation is also completely unknown (ref.2). Here we demonstrate that eCAGr RNA may form gel-like condensates (foci) in the cytopl...

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Literature Corpus work: cb3a2577-f2c4-5e09-a175-6548fd0e0cf1
DOI: 10.21203/rs.3.rs-541829/v1

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