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Article

Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD.

Nature communications - 13 Aug 2021

Wang Shaopeng, Latallo Malgorzata J, Zhang Zhe, Huang Bo, Bobrovnikov Dmitriy G, Dong Daoyuan, Livingston Nathan M, Tjoeng Wilson, Hayes Lindsey R, Rothstein Jeffrey D, Ostrow Lyle W, Wu Bin, Sun Shuying

Abstract excerpt

C9ORF72 hexanucleotide GGGGCC repeat expansion is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat-containing RNA mediates toxicity through nuclear granules and dipeptide repeat (DPR) proteins produced by repeat-associated non-AUG translation. However, it remains unclear how the intron-localized repeats are exported and translated in the cytoplasm. We...

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Identifiers

PMID: 34389711
DOI: 10.1038/s41467-021-25082-9
PMCID: PMC8363653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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