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Article

Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs

9 Jan 2023

Abstract excerpt

CAG trinucleotide repeat expansions cause several neurodegenerative diseases, including Huntington's disease and spinocerebellar ataxia. RNAs with expanded CAG repeats contribute to disease in two unusual ways. First, these repeat-containing RNAs may agglomerate in the nucleus as foci that sequester several RNA-binding proteins. Second, these RNAs may undergo aberrant repeat-associated non-AUG (RAN) translation...

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PMID: 36623192
DOI: 10.1073/pnas.2215071120

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