Assessing vision and autism spectrum disorder-relevant social interaction phenotypes in Dscam mice.

Abstract excerpt

Down syndrome cell adhesion molecule (DSCAM) is an immunoglobulin-superfamily cell-adhesion molecule important for neuronal survival, morphogenesis, synaptic specificity, and particularly retinal organization. Pathogenic variants in Dscam have been linked to developmental disorders including Autism Spectrum Disorder (ASD), Down Syndrome (DS), developmental delays and intellectual disabilities. Here we work to...

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