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Article

Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer.

Neurobiology of disease - 1 Aug 2011

Faizi Mehrdad, Bader Patrick L, Tun Christine, Encarnacion Angelo, Kleschevnikov Alexander, Belichenko Pavel, Saw Nay, Priestley Matthew, Tsien Richard W, Mobley William C, Shamloo Mehrdad

Abstract excerpt

Down syndrome (DS) is the most prevalent form of mental retardation caused by genetic abnormalities in humans. This has been successfully modeled in mice to generate the Ts65Dn mouse, a genetic model of DS. This transgenic mouse model shares a number of physical and functional abnormalities with people with DS, including changes in the structure and function of neuronal circuits. Significant abnormalities in...

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Identifiers

PMID: 21527343
DOI: 10.1016/j.nbd.2011.04.011
PMCID: PMC3539757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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