Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of NEK2A in Human Cancer and Its Therapeutic Potentials

1 Jan 2015

Abstract excerpt

Chromosome instability (CIN) has been identified as a common feature of most human cancers. A number of centrosomal kinases are thought to cause CIN in cancer cells. Part of those centrosomal kinases exhibit elevated expression in a wide variety of tumours and cancer cell lines. Additionally, critical roles in many aspects of cancer cell growth, proliferation, metastasis, and drug resistance have been assigned to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Microtubule and mitosis dynamics
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25705694
DOI: 10.1155/2015/862461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of NEK2A in Human Cancer and Its Therapeutic PotentialsPMID 25705694Read ↗

Targeting NEK2 as a promising therapeutic approach for cancer treatmentSemantic proximity Read ↗

A Comprehensive Analysis Revealing NEK2 as an oncogene in the Tumor MicroenvironmentSemantic proximity Read ↗

The NIMA-related kinase family and cancerSemantic proximity Read ↗

NEK2 is a potential pan-cancer biomarker and immunotherapy targetSemantic proximity Read ↗

Upregulation of NEK2 is associated with drug resistance in ovarian cancerSemantic proximity Read ↗

NIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferationSemantic proximity Read ↗

NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer TypesSemantic proximity Read ↗

Less is More: Nek2A Unclusters Extra Centrosomes and Induces Cell Death in Cancer Cells via KIF2C InteractionSemantic proximity Read ↗

Aurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A ReviewSemantic proximity Read ↗

On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage ResponseSemantic proximity Read ↗

Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.Semantic proximity Read ↗

Pan-Cancer Genetic Profiles of Mitotic DNA Integrity Checkpoint Protein KinasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.