Article

β-amyloid−driven synaptic depression requires PDZ protein interaction at AMPA-receptor subunit GluA3

2021-10-05

Abstract excerpt

Soluble oligomeric amyloid-β (Aβ) is a prime suspect to cause cognitive deficits in Alzheimer’s disease and weakens synapses by removing AMPA-type glutamate receptors (AMPARs). We show that synapses of CA1 pyramidal neurons become vulnerable to Aβ when they express AMPAR subunit GluA3. We found that Aβ-oligomers reduce the levels of GluA3 immobilized at spines, indicating they deplete GluA3-containing AMPARs from...

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Literature Corpus work: cae22046-ede6-553a-8908-643e8eb1a524
DOI: 10.1101/2021.10.03.462970

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