Article

Caspase cleavage of APP contributes to amyloid beta-protein induced synaptic injury

2025-05-07

Abstract excerpt

<h4>BACKGROUND</h4> Increasing evidence suggests that amyloid beta (Aβ) lies at the center of Alzheimer’s Disease (AD) pathology and that synapses are the initial site of damage by Aβ. Recent studies have also indicated a role for caspases in AD-related synaptic dysfunction and memory loss, but the mechanism(s) through which the caspases act remains elusive. Previous studies in cell culture indicate that cleavage...

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Literature Corpus work: 4f70e5b7-6778-57d6-b059-71ba7c19e5ee
DOI: 10.1101/2025.04.30.651606

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