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Article

PSD-93 Attenuates Amyloid-β-Mediated Cognitive Dysfunction by Promoting the Catabolism of Amyloid-β.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Yu Linjie, Liu Yi, Yang Hui, Zhu Xiaolei, Cao Xiang, Gao Jun, Zhao Hui, Xu Yun

Abstract excerpt

Amyloid-β (Aβ) is a key neuropathological hallmark of Alzheimer's disease (AD). Postsynaptic density protein 93 (PSD-93) is a key scaffolding protein enriched at postsynaptic sites. The aim of the present study was to examine whether PSD-93 overexpression could alleviate Aβ-induced cognitive dysfunction in APPswe/PS1dE9 (APP/PS1) mice by reducing Aβ levels in the brain. The level of PSD-93 was significantly...

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Source

Identifiers

PMID: 28697571
DOI: 10.3233/JAD-170320

Genes

PSD
APP
SSTR4

Provenance

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