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Article

Blockade of dopamine D3 receptors improves hippocampal synaptic function and rescues age-related cognitive phenotype.

Aging cell - 1 Nov 2024

Tropea Maria Rosaria, Melone Marcello, Li Puma Domenica Donatella, Vacanti Valeria, Aceto Giuseppe, Bandiera Bruno, Trovato Roberta Carmela, Torrisi Sebastiano Alfio, Leggio Gian Marco, Palmeri Agostino, D'Ascenzo Marcello, Conti Fiorenzo, Grassi Claudio, Puzzo Daniela

Abstract excerpt

Dopamine D3 receptors (D3Rs) modulate neuronal activity in several brain regions including the hippocampus. Although previous studies reported that blocking D3Rs exerts pro-cognitive effects, their involvement in hippocampal synaptic function and memory in the healthy and aged brain has not been thoroughly investigated. We demonstrated that in adult wild type (WT) mice, D3R pharmacological blockade or genetic...

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PMID: 39236310
DOI: 10.1111/acel.14291
PMCID: PMC11561665

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PSD

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