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Article

Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A

5 Oct 2012

Abstract excerpt

Although tumour suppressor gene hypermethylation is a universal feature of cancer cells, little is known about the necessary molecular triggers. Here, we show that Wilms' tumour 1 (WT1), a developmental master regulator that can also act as a tumour suppressor or oncoprotein, transcriptionally regulates the de novo DNA methyltransferase 3A (DNMT3A) and that cellular WT1 levels can influence DNA methylation of...

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PMID: 23042785
DOI: 10.1093/hmg/dds403

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