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Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B

23 Jan 2023

Abstract excerpt

DNA methylation is a repressive epigenetic modification that is essential for development, exemplified by the embryonic and perinatal lethality observed in mice lacking de novo DNA methyltransferases (DNMTs). Here we characterise the role for DNMT3A, 3B and 3L in gene regulation and development of the mouse placenta. We find that each DNMT establishes unique aspects of the placental methylome through targeting to...

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PMID: 36690623
DOI: 10.1038/s41467-023-36019-9

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