Article
Th17 cells with regulatory phenotype are the main IL-17F and IL-26 producers in palmoplantar pustulosis.
JCI insight - 23 Sept 2025
Do Tran H, Bogle Rachael, Zhang Haihan, Xing Xianying, Gharaee-Kermani Mehrnaz, Raducu Madalina, Fox Jennifer, Jiang Rundong, Plazyo Olesya, Harms Paul W, Nakamura Mio, Xing Enze, Gilliet Michel, Billi Allison C, Kahlenberg J Michelle, Modlin Robert L, Uluckan Ozge, Tsoi Lam C, Gudjonsson Johann E
Abstract excerpt
Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disorder marked by erythematous pustules and desquamation on the palms and soles. While IL-17 pathways are implicated in PPP, IL-17 blockers have shown modest efficacy, underscoring the need for a deeper understanding of IL-17 involvement. To dissect the cellular and spatial architecture of PPP, we performed single-cell RNA-Seq (scRNA-Seq) on lesional,...
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