Article

Clonal sharing of CD8+ T-cells links skin and joint inflammation in psoriatic arthritis

2024-05-12

Abstract excerpt

We hypothesised that skin and joint inflammation in psoriatic arthritis (PsA) is linked in terms of CD8+ T-cell phenotype and clonality. We employed scRNAseq to directly compare the transcriptional signature and T-cell receptor repertoire of memory T-cells from paired skin and synovial tissue and/or fluid from patients with PsA. We identified an enrichment of type-17 CD8+ tissue-resident memory (T RM ) T-cells in...

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Literature Corpus work: 5cca7392-ef4a-5777-b88c-f6e94cfefeff
DOI: 10.1101/2024.05.09.593313

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