Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8 + T Cell Clones

Abstract excerpt

Objective Psoriatic arthritis (PsA) is an HLA class I–associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8 + T cell phenotype and clonality. Methods Using single‐cell RNA sequencing (n = 6 skin samples with n = 5 paired synovial tissue samples and/or n = 5 paired synovial fluid samples) and...

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• Psoriasis: Treatment and Pathogenesis
• Rheumatoid Arthritis Research and Therapies
• Spondyloarthritis Studies and Treatments