Article

Distinct tissue-niche localization and function of synovial tissue myeloid DC subsets in health, and in active and remission Rheumatoid Arthritis

2024-07-19

Abstract excerpt

<h4>Summary</h4> Current rheumatoid arthritis (RA) treatments do not restore immune tolerance. Investigating dendritic cell (DC) populations in human synovial tissue (ST) may reveal pathways to re-instate tolerance in RA. With single-cell and spatial-transcriptomics of synovial tissue biopsies, validated by micro co-culture systems, we identified condition and niche-specific myeloid DC clusters with distinct diff...

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Literature Corpus work: 0ca5f441-98fc-5722-ac8a-97aa28314710
DOI: 10.1101/2024.07.17.600758

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