Article

Highlighting fibroblast plasticity in lung fibrosis: the WI-38 cell line as a model for investigating the myofibroblast and lipofibroblast switch

2023-12-22

Abstract excerpt

<h4>Background</h4> Myofibroblasts (MYFs) are generally considered the principal culprits in excessive extracellular matrix deposition and scar formation in the pathogenesis of lung fibrosis. Lipofibroblasts (LIFs), on the other hand, are defined by their lipid-storing capacity and are predominantly found in the alveolar regions of the lung. They have been proposed to play a protective role in lung fibrosis. We p...

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Literature Corpus work: caa07315-b7d0-5092-b932-534a2bdcd79e
DOI: 10.1101/2023.12.22.572972

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