Article
Highlighting fibroblast plasticity in lung fibrosis: the WI-38 cell line as a model for investigating the myofibroblast and lipofibroblast switch.
Theranostics - 1 Jan 2024
Vásquez-Pacheco Esmeralda, Marega Manuela, Lingampally Arun, Fassy Julien, Truchi Marin, Goth Kerstin, Trygub Lisa, Taghizadeh Sara, Bartkuhn Marek, Alexopoulos Ioannis, Dong Ying, Lebrigand Kevin, Gunther Andreas, Chen Chengshui, Zhang JinSan, Chao Cho-Ming, Al Alam Denise, El Agha Elie, Mari Bernard, Bellusci Saverio, Rivetti Stefano
Abstract excerpt
Background: Myofibroblasts (MYFs) are generally considered the principal culprits in excessive extracellular matrix deposition and scar formation in the pathogenesis of lung fibrosis. Lipofibroblasts (LIFs), on the other hand, are defined by their lipid-storing capacity and are predominantly found in the alveolar regions of the lung. They have been proposed to play a protective role in lung fibrosis. We...
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