Article

Lineage-tracing of <i>Acta2</i> + cells in aged mice during lung fibrosis formation and resolution supports the lipofibroblast to myofibroblast reversible switch

2024-02-22

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) develops mostly in old man and is characterized by the irreversible accumulation of excessive extracellular matrix components by activated myofibroblasts (aMYFs) leading to lung failure. Following bleomycin administration in young mice, fibrosis formation associated with efficient resolution takes place, the later limiting the clinical relevance of this model for IPF. In young m...

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Literature Corpus work: 6e26252e-b4cd-5620-80bf-832381e930f8
DOI: 10.1101/2024.02.19.580952

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Lineage-tracing of <i>Acta2</i> + cells in aged mice during lung fibrosis formation and resolution supports the lipofibroblast to myofibroblast reversible switchDOI 10.1101/2024.02.19.580952Read

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