Article

Modeling of Aberrant Epithelial Reprogramming in Idiopathic Pulmonary Fibrosis using Human Induced Pluripotent Stem Cell-derived Alveolar Organoids

2022-06-15

Abstract excerpt

Repeated injury of the lung epithelium is proposed to be a main driver of idiopathic pulmonary fibrosis (IPF). However, none of the available therapies target the epithelium and there is a limited amount of human models of fibrotic epithelial damage with suitability for drug screening and discovery. We developed a model of the epithelial reprogramming seen in IPF using alveolar organoids derived from human induced...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7ed93428-c0a1-566f-bc1c-020635606d64
DOI: 10.1101/2022.06.15.496102

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modeling of Aberrant Epithelial Reprogramming in Idiopathic Pulmonary Fibrosis using Human Induced Pluripotent Stem Cell-derived Alveolar OrganoidsDOI 10.1101/2022.06.15.496102Read

Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic TargetsSemantic proximity Read

Pathogenic Mechanisms Underlying Idiopathic Pulmonary FibrosisSemantic proximity Read

Modeling cell-cell interactions to advance drug discovery in Idiopathic Pulmonary FibrosisSemantic proximity Read

Targeting the epithelium in pulmonary fibrosis.Semantic proximity Read

Airway Basal Cells show a dedifferentiated KRT17 <sup>high</sup> Phenotype and promote Fibrosis in Idiopathic Pulmonary FibrosisSemantic proximity Read

<i>Ex vivo</i> tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesisSemantic proximity Read

Profibrotic priming of airway cell types and drug responses in early-stage idiopathic pulmonary fibrosisSemantic proximity Read

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosisSemantic proximity Read

Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in an iPSC-derived air-liquid interface modelSemantic proximity Read

Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis.Semantic proximity Read

Progressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epitheliumSemantic proximity Read

Mapping fibroblast plasticity across non-cancer lung diseases at single-cell resolutionSemantic proximity Read