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Article

Functional Pdgfra fibroblast heterogeneity in normal and fibrotic mouse lung

12 Oct 2023

Abstract excerpt

Aberrant fibroblast function plays a key role in the pathogenesis of idiopathic pulmonary fibrosis, a devastating disease of unrelenting extracellular matrix deposition in response to lung injury. Platelet-derived growth factor α-positive (Pdgfra+) lipofibroblasts (LipoFBs) are essential for lung injury response and maintenance of a functional alveolar stem cell niche. Little is known about the effects of lung...

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PMID: 37824216
DOI: 10.1172/jci.insight.164380

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