Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis.

doi:10.1016/j.stem.2016.10.004

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Article

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis.

Cell stem cell - 2 Feb 2017

El Agha Elie, Moiseenko Alena, Kheirollahi Vahid, De Langhe Stijn, Crnkovic Slaven, Kwapiszewska Grazyna, Szibor Marten, Kosanovic Djuro, Schwind Felix, Schermuly Ralph T, Henneke Ingrid, MacKenzie BreAnne, Quantius Jennifer, Herold Susanne, Ntokou Aglaia, Ahlbrecht Katrin, Braun Thomas, Morty Rory E, Günther Andreas, Seeger Werner, Bellusci Saverio

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a form of progressive interstitial lung disease with unknown etiology. Due to a lack of effective treatment, IPF is associated with a high mortality rate. The hallmark feature of this disease is the accumulation of activated myofibroblasts that excessively deposit extracellular matrix proteins, thus compromising lung architecture and function and hindering gas exchange. Here...

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PMID: 27867035
DOI: 10.1016/j.stem.2016.10.004
PMCID: PMC5291816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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