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Article

Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID

5 Dec 2019

Abstract excerpt

The prerequisite to prevent childhood B-cell acute lymphoblastic leukemia (B-ALL) is to decipher its etiology. The current model suggests that infection triggers B-ALL development through induction of activation-induced cytidine deaminase (AID; also known as AICDA) in precursor B-cells. This evidence has been largely acquired through the use of ex vivo functional studies. However, whether this mechanism governs...

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PMID: 31804490
DOI: 10.1038/s41467-019-13570-y

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