Article

Structure and Neutralization Mechanism of a Human Antibody Targeting a Complex Epitope on Zika Virus

2022-08-23

Abstract excerpt

We currently have an incomplete understanding of why only a fraction of human antibodies that bind to flaviviruses block infection of cells. Here we define the footprint of a strongly neutralizing human monoclonal antibody (mAb G9E) with Zika virus (ZIKV) by both X-ray crystallography and cryo-electron microscopy. Flavivirus envelope (E) glycoproteins are present as homodimers on the virion surface, and G9E bound...

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Literature Corpus work: f6b22a6c-df5d-5c47-9cb6-029c838428b5
DOI: 10.1101/2022.08.22.504902

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