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Structural basis of broad SARS-CoV-2 cross-neutralization by affinity-matured public antibodies

17 May 2024

Abstract excerpt

Descendants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant now account for almost all SARS-CoV-2 infections. The Omicron variant and its sublineages have spike glycoproteins that are highly diverged from the pandemic founder and first-generation vaccine strain, resulting in significant evasion from monoclonal antibody therapeutics and vaccines. Understanding how commonly...

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PMID: 38761799
DOI: 10.1016/j.xcrm.2024.101577

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