Article

Antibody avidity and multi-specificity combined to confer protection against SARS-CoV-2 and resilience against viral escape

2022-10-24

Abstract excerpt

SARS-CoV-2, the causative agent of COVID-19, has been responsible for a global pandemic. Monoclonal antibodies have been used as antiviral therapeutics, but have been limited in efficacy by viral sequence variability in emerging variants of concern (VOCs), and in deployment by the need for high doses. In this study, we leverage the MULTI-specific, multi-Affinity antiBODY (Multabody, MB) platform, derived from the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 850d72e4-77cb-54b1-ab69-f38380e8c056
DOI: 10.1101/2022.10.23.513379

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antibody avidity and multi-specificity combined to confer protection against SARS-CoV-2 and resilience against viral escapeDOI 10.1101/2022.10.23.513379Read

One Thousand SARS-CoV-2 Antibody Structures Reveal Convergent Binding and Near-Universal Immune EscapeSemantic proximity Read

Structural and mutational analyses define distinct molecular routes to broad SARS-CoV-2 receptor-binding domain recognitionSemantic proximity Read

A multispecific antibody prevents immune escape and confers pan-SARS-CoV-2 neutralizationSemantic proximity Read

Optimizing a Human Monoclonal Antibody for Better Neutralization of SARS-CoV-2Semantic proximity Read

Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protectionSemantic proximity Read

Broadening a SARS-CoV-1–neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolutionSemantic proximity Read

Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster modelsSemantic proximity Read

A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversificationSemantic proximity Read

Broad Neutralization Activity of SARS-CoV-2 Antibody is Achieved by Coordinated Recognition of Virus Vulnerable SiteSemantic proximity Read

Superimmunity by pan-sarbecovirus nanobodiesSemantic proximity Read

Application of an integrated computational antibody engineering platform to design SARS-CoV-2 neutralizersSemantic proximity Read

Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccinationSemantic proximity Read