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Neutralization mechanism of a highly potent antibody against Zika virus

24 Nov 2016

Abstract excerpt

The rapid spread of Zika virus (ZIKV), which causes microcephaly and Guillain-Barré syndrome, signals an urgency to identify therapeutics. Recent efforts to rescreen dengue virus human antibodies for ZIKV cross-neutralization activity showed antibody C10 as one of the most potent. To investigate the ability of the antibody to block fusion, we determined the cryoEM structures of the C10-ZIKV complex at pH levels...

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PMID: 27882950
DOI: 10.1038/ncomms13679

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