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Article

Reevaluation of SNP heritability in complex human traits.

Nature genetics - 1 Jul 2017

Speed Doug, Cai Na, Johnson Michael R, Nejentsev Sergey, Balding David J

Abstract excerpt

SNP heritability, the proportion of phenotypic variance explained by SNPs, has been reported for many hundreds of traits. Its estimation requires strong prior assumptions about the distribution of heritability across the genome, but current assumptions have not been thoroughly tested. By analyzing imputed data for a large number of human traits, we empirically derive a model that more accurately describes how...

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PMID: 28530675
DOI: 10.1038/ng.3865
PMCID: PMC5493198

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