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Article

Frailty and genetics: linking molecular aging to clinical vulnerability.

The journals of gerontology. Series A, Biological sciences and medical sciences - 7 Apr 2026

Castillo Jhuliana, García Natalia, Gómez Fernando

Abstract excerpt

Aging is a multifactorial process involving cumulative cellular and molecular damage, directly affecting physiological reserve and homeostasis. In this context, frailty emerges as a complex, dynamic, and potentially reversible geriatric syndrome, associated with inflammatory dysregulation, immunosenescence, and genetic alterations. This narrative review presents the most recent findings linking frailty to genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41968832
DOI: 10.1093/gerona/glag088
PMCID: PMC13120882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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