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Article

Physical frailty, genetic risk, mediating biomarkers, and risk of suicide attempt: A prospective cohort study.

PLoS medicine - 1 Apr 2026

Hu Wei, Gao Li-Jie, Liu Tian-Shu, Tian Ge, Wang Jia-Ning, Ma Yu-Bin, Zheng Zi-Ang, Feng Tong-Jie, Niu Xiao-Xin, Yan Yi-Ning, Liu Bao-Peng, Jia Cun-Xian

Abstract excerpt

BACKGROUND: While physical frailty is linked to psychiatric disorders, its association with suicide attempt (SA) risk is unclear. We aimed to investigate the prospective association of physical frailty with SA risk and the modifying and potential mediating roles of genetic risk and blood biomarkers. METHODS AND FINDINGS: This cohort study included 442,920 UK Biobank participants free of SA at baseline. SA events...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41941430
DOI: 10.1371/journal.pmed.1005045
PMCID: PMC13065332

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