Article

Segregation analysis of 17,425 population-based breast cancer families: evidence for genetic susceptibility and risk prediction

2022-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Rare pathogenic variants in known breast cancer susceptibility genes and known common susceptibility variants do not fully explain the familial aggregation of breast cancer. To investigate plausible genetic models for the residual familial aggregation, we studied 17,425 families ascertained through population-based probands, 86% of whom were screened for pathogenic variants in BRCA1, BRCA2, PALB2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 46162a15-9c45-57ce-ad53-3b3891c0a15f
DOI: 10.1101/2022.05.24.22275555

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Segregation analysis of 17,425 population-based breast cancer families: evidence for genetic susceptibility and risk predictionDOI 10.1101/2022.05.24.22275555Read

Segregation analysis of 17,425 population-based breast cancer families: Evidence for genetic susceptibility and risk prediction.Semantic proximity Read

Polygenic risk, susceptibility genes, and breast cancer over the life courseSemantic proximity Read

Understanding genetic variations associated with familial breast cancer.Semantic proximity Read

Hereditary Breast Cancer: Comprehensive Risk Assessment and Prevention StrategiesSemantic proximity Read

Polygenic Risk Scores for Breast Cancer: Modern Approaches to Risk Prediction and Subtype Identification.Semantic proximity Read

Genetic assessments of breast cancer risk that do not account for polygenic background are incomplete and lead to incorrect preventative strategiesSemantic proximity Read

Overlap of high-risk individuals across family history, genetic & non-genetic breast cancer risk models: Analysis of 180,398 women from European & Asian ancestriesSemantic proximity Read

Genomic risk prediction for breast cancer in older womenSemantic proximity Read

BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors.Semantic proximity Read

Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models: implications for risk stratification.Semantic proximity Read

Clustering of known low and moderate risk alleles rather than a novel recessive high-risk gene in non-BRCA1/2 sib trios affected with breast cancer.Semantic proximity Read

Common Genetic Variation and Breast Cancer Risk-Past, Present, and Future.Semantic proximity Read