Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissecting the heritable risk of breast cancer: From statistical methods to susceptibility genes.

Seminars in cancer biology - 1 Jul 2021

Fanfani Viola, Zatopkova Martina, Harris Adrian L, Pezzella Francesco, Stracquadanio Giovanni

Abstract excerpt

Decades of research have shown that rare highly penetrant mutations can promote tumorigenesis, but it is still unclear whether variants observed at high-frequency in the broader population could modulate the risk of developing cancer. Genome-wide Association Studies (GWAS) have generated a wealth of data linking single nucleotide polymorphisms (SNPs) to increased cancer risk, but the effect of these mutations are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Models, Statistical

Share to Polymorphism, Single Nucleotide

Share to Prognosis

Source

Identifiers

PMID: 32569822
DOI: 10.1016/j.semcancer.2020.06.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissecting the heritable risk of breast cancer: From statistical methods to susceptibility genes.PMID 32569822Read ↗

The impact of next generation sequencing on the analysis of breast cancer susceptibility: a role for extremely rare genetic variation?Semantic proximity Read ↗

Genetic susceptibility to breast cancer.Semantic proximity Read ↗

Common Genetic Variation and Breast Cancer Risk-Past, Present, and Future.Semantic proximity Read ↗

From candidate gene studies to GWAS and post-GWAS analyses in breast cancer.Semantic proximity Read ↗

Germline DNA variations in breast cancer predisposition and prognosis: a systematic review of the literature.Semantic proximity Read ↗

Breast cancer genetics: what we know and what we need.Semantic proximity Read ↗

Genetic determinants of breast cancer risk: a review of current literature and issues pertaining to clinical application.Semantic proximity Read ↗

Polygenic susceptibility to breast cancer: current state-of-the-art.Semantic proximity Read ↗

Gene-level heritability analysis explains the polygenic architecture of cancerSemantic proximity Read ↗

The genetics of breast cancer risk in the post-genome era: thoughts on study design to move past BRCA and towards clinical relevance.Semantic proximity Read ↗

The emerging landscape of breast cancer susceptibility.Semantic proximity Read ↗

Breast cancer genetics and risk assessment: an overview for the clinician.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.