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Article

Deep targeted sequencing of 12 breast cancer susceptibility regions in 4611 women across four different ethnicities.

Breast cancer research : BCR - 5 Nov 2016

Lindström Sara, Ablorh Akweley, Chapman Brad, Gusev Alexander, Chen Gary, Turman Constance, Eliassen A Heather, Price Alkes L, Henderson Brian E, Le Marchand Loic, Hofmann Oliver, Haiman Christopher A, Kraft Peter

Abstract excerpt

BACKGROUND: Although genome-wide association studies (GWASs) have identified thousands of disease susceptibility regions, the underlying causal mechanism in these regions is not fully known. It is likely that the GWAS signal originates from one or many as yet unidentified causal variants. METHODS: Using next-generation sequencing, we characterized 12 breast cancer susceptibility regions identified by GWASs in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27814745
DOI: 10.1186/s13058-016-0772-7
PMCID: PMC5097387

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