A comprehensive examination of breast cancer risk loci in African American women.

doi:10.1093/hmg/ddu252

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A comprehensive examination of breast cancer risk loci in African American women.

Human molecular genetics - 15 Oct 2014

Feng Ye, Stram Daniel O, Rhie Suhn Kyong, Millikan Robert C, Ambrosone Christine B, John Esther M, Bernstein Leslie, Zheng Wei, Olshan Andrew F, Hu Jennifer J, Ziegler Regina G, Nyante Sarah, Bandera Elisa V, Ingles Sue A, Press Michael F, Deming Sandra L, Rodriguez-Gil Jorge L, Palmer Julie R, Olopade Olufunmilayo I, Huo Dezheng, Adebamowo Clement A, Ogundiran Temidayo, Chen Gary K, Stram Alex, Park Karen, Rand Kristin A, Chanock Stephen J, Le Marchand Loic, Kolonel Laurence N, Conti David V, Easton Douglas, Henderson Brian E, Haiman Christopher A

Abstract excerpt

Genome-wide association studies have identified 73 breast cancer risk variants mainly in European populations. Given considerable differences in linkage disequilibrium structure between populations of European and African ancestry, the known risk variants may not be informative for risk in African ancestry populations. In a previous fine-mapping investigation of 19 breast cancer loci, we were able to identify...

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PMID: 24852375
DOI: 10.1093/hmg/ddu252
PMCID: PMC4168823

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