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Article

Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer.

Trends in genetics : TIG - 1 Mar 2010

Galvan Antonella, Ioannidis John P A, Dragani Tommaso A

Abstract excerpt

Genome-wide association studies (GWAS) using population-based designs have identified many genetic loci associated with risk of a range of complex diseases including cancer; however, each locus exerts a very small effect and most heritability remains unexplained. Family-based pedigree studies have also suggested tentative loci linked to increased cancer risk, often characterized by pedigree-specificity. However,...

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Identifiers

PMID: 20106545
DOI: 10.1016/j.tig.2009.12.008
PMCID: PMC2826571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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