Article
Family Study Designs Informed by Tumor Heterogeneity and Multi-Cancer Pleiotropies: The Power of the Utah Population Database.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2020
Hanson Heidi A, Leiser Claire L, Madsen Michael J, Gardner John, Knight Stacey, Cessna Melissa, Sweeney Carol, Doherty Jennifer A, Smith Ken R, Bernard Philip S, Camp Nicola J
Abstract excerpt
BACKGROUND: Previously, family-based designs and high-risk pedigrees have illustrated value for the discovery of high- and intermediate-risk germline breast cancer susceptibility genes. However, genetic heterogeneity is a major obstacle hindering progress. New strategies and analytic approaches will be necessary to make further advances. One opportunity with the potential to address heterogeneity via improved...
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