Article
Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers.
Carcinogenesis - 1 Jul 2013
Zheng Yonglan, Ogundiran Temidayo O, Falusi Adeyinka G, Nathanson Katherine L, John Esther M, Hennis Anselm J M, Ambs Stefan, Domchek Susan M, Rebbeck Timothy R, Simon Michael S, Nemesure Barbara, Wu Suh-Yuh, Leske Maria Cristina, Odetunde Abayomi, Niu Qun, Zhang Jing, Afolabi Chibuzor, Gamazon Eric R, Cox Nancy J, Olopade Christopher O, Olopade Olufunmilayo I, Huo Dezheng
Abstract excerpt
Numerous single nucleotide polymorphisms (SNPs) associated with breast cancer susceptibility have been identified by genome-wide association studies (GWAS). However, these SNPs were primarily discovered and validated in women of European and Asian ancestry. Because linkage disequilibrium is ancestry-dependent and heterogeneous among racial/ethnic populations, we evaluated common genetic variants at 22...
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