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Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites

3 Nov 2017

Abstract excerpt

An unusual genome architecture characterizes the two related human parasitic pathogens Plasmodium falciparum and Toxoplasma gondii. A major fraction of the bulk parasite genome is packaged as transcriptionally permissive euchromatin with few loci embedded in silenced heterochromatin. Primary chromatin shapers include histone modifications at the nucleosome lateral surface close to the DNA but their mode of action...

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PMID: 29101771
DOI: 10.7554/elife.29391

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