Article

Non-neutral evolution of H3.3-encoding genes occurs without alterations in protein sequence

2018-09-20

Abstract excerpt

Histone H3.3 is a developmentally essential variant encoded by two independent genes in human ( H3F3A and H3F3B ). While this two-gene arrangement is evolutionarily conserved, its origins and function remain unknown. Phylogenetics, synteny and gene structure analyses of the H3.3 genes from 32 metazoan genomes indicate independent evolutionary paths for H3F3A and H3F3B . While H3F3B bears similarities with H3....

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Literature Corpus work: 89d615c6-638b-58bf-9e48-4025b4057e91
DOI: 10.1101/422311

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