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Three Distinct Patterns of Histone H3Y41 Phosphorylation Mark Active Genes

1 Sept 2012

Abstract excerpt

The JAK2 tyrosine kinase is a critical mediator of cytokine-induced signaling. It plays a role in the nucleus, where it regulates transcription by phosphorylating histone H3 at tyrosine 41 (H3Y41ph). We used chromatin immunoprecipitation coupled to massively parallel DNA sequencing (ChIP-seq) to define the genome-wide pattern of H3Y41ph in human erythroid leukemia cells. Our results indicate that H3Y41ph is...

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PMID: 22999934
DOI: 10.1016/j.celrep.2012.08.016

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