Article
Identification of novel allosteric modulator binding sites in NMDA receptors: A molecular modeling study.
Journal of molecular graphics & modelling - 1 Sept 2015
Kane Lucas T, Costa Blaise M
Abstract excerpt
The dysfunction of N-methyl-d-Aspartate receptors (NMDARs), a subtype of glutamate receptors, is correlated with schizophrenia, stroke, and many other neuropathological disorders. However, not all NMDAR subtypes equally contribute towards these disorders. Since NMDARs composed of different GluN2 subunits (GluN2A-D) confer varied physiological properties and have different distributions in the brain,...
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