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Dual Role of NMDAR Containing NR2A and NR2B Subunits in Alzheimer’s Disease

26 Apr 2024

Abstract excerpt

Alzheimer's disease (AD) is the main cause of dementia worldwide. Given that learning and memory are impaired in this pathology, NMDA receptors (NMDARs) appear as key players in the onset and progression of the disease. NMDARs are glutamate receptors, mainly located at the post-synapse, which regulate voltage-dependent influx of calcium into the neurons. They are heterotetramers, and there are different subunits...

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PMID: 38731978
DOI: 10.3390/ijms25094757

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